B-cell maturation antigen (BCMA) is a cell surface receptor encoded by TNFRSF17 gene and belongs to the TNF receptor superfamily. It is preferentially expressed in certain types of B cells including healthy plasma cells and has been shown to be of vital importance in B cell development and autoimmune response involving NF-kB and MAPK8/JNK activation. BCMA is an ideal target for immunotherapy as it is nearly uniformly expressed by the malignant plasma cells of most patients with Multiple Myeloma (MM) while has very low expression in other malignant or non-malignant tissues.
Learn more: anti-BCMA CAR-T in vivo assay