Radionuclide Screening and Synthesis Service

Radionuclide Screening and Synthesis Service

by adam wilson -
Number of replies: 3

The radionuclide is an essential part of the acting part of RDC (Radionuclide Drug Conjugate), which can play a role in killing cancer cells and diagnostic imaging. Types of radionuclides are approved for application in RDC nowadays.

Rdcthera, as a professional CRO company, can provide radionuclide synthesis service. Since we have synthesis services for a wide range of radionuclides, we are capable of radionuclide screening to find the most suitable radionuclide in your specific RDC development.

Overview of Radionuclides

The radioactive particle is the effective part of the radiopharmaceutical, which can emit β- or α- beams to deliver radiation directly to the tumor cells. For a given chemical element, radionuclides have the same number of protons in each atom, but they have different numbers of neutrons. In theory, all chemical elements in nature can exist as radionuclides.

As the radionuclide is too small to be stable in patients, it can be chelated with antibodies, small molecules, and peptides to maintain stability. A myriad of radionuclides has been conjugated with ligand applied for clinical research. The radionuclide in RDC works as the cell-damaging tool and the diagnostic tool imaging by PET or SPECT. There are three types of radionuclides that are most commonly used in RDC.

Learn more：Radionuclide Synthesis

In reply to adam wilson

Re: Radionuclide Screening and Synthesis Service

by Latonya Dodson -

It seems that you are interested in radionuclide drug conjugates (RDCs), a novel form of targeted cancer therapy that uses radioactive particles to deliver radiation to tumor cells. RDCs consist of a ligand, such as an antibody or a peptide, that binds to a specific antigen on the cancer cells, a linker that connects the ligand to a chelator, and a radionuclide that is chelated by the chelator. The radionuclide can emit beta or alpha particles that can kill the cancer cells, as well as gamma rays that can be detected by imaging techniques such as PET or SPECT.

According to my web search results, there are three types of radionuclides that are most commonly used in RDCs: Be Ball Players

Therapeutic radionuclides, such as lutetium-177 (177Lu), yttrium-90 (90Y), actinium-225 (225Ac), and astatine-211 (211At), that have high energy and short range, and can cause significant damage to the tumor cells and minimal damage to the surrounding normal tissues12.

Diagnostic radionuclides, such as gallium-68 (68Ga), fluorine-18 (18F), and zirconium-89 (89Zr), that have low energy and long range, and can provide high-resolution images of the tumor location, size, and activity13.

Theranostic radionuclides, such as copper-64 (64Cu) and iodine-131 (131I), that have both therapeutic and diagnostic properties, and can enable personalized dosimetry, treatment monitoring, and response evaluation14.

Rdcthera, as a professional CRO company, can provide radionuclide synthesis service for your RDC development. They claim to have synthesis services for a wide range of radionuclides, and can perform radionuclide screening to find the most suitable radionuclide for your specific RDC project. You can learn more about their services and contact them through their website5.

I hope this information is helpful for you.